The effect of fluoride on Streptococcus sanguis 7863 IGA1 protease production and activity

Fluoride was found to affect the production of the bacterial IgAl protease but to have no effect on IgAl protease activity. The concentrations of fluoride that do affect Streptococcus sanguis growth and IgAl protease production are higher than those normally seen in vivo under normal circumstances. The concentrations of fluoride in dental plaque following use of a fluoride rinse or dentifrice would be sufficient to reduce Strep. sanguis IgAl protease production.