Title of article
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors
Author/Authors
Tao، نويسنده , , Lianhui and Yang، نويسنده , , Siming and Xie، نويسنده , , Mi and Kramer، نويسنده , , Paula M and Pereira، نويسنده , , Michael A، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
9
From page
185
To page
193
Abstract
Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c-myc genes, expression of both genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity.
Keywords
dichloroacetic acid , Trichloroacetic acid , Mouse liver tumor , C-jun , c-Myc , DNA methylation
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801770
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