Title of article
Cancer chemopreventive activity of 3,5,6,7,8,3′,4′-heptamethoxyflavone from the peel of citrus plants
Author/Authors
Iwase ، نويسنده , , Yukiko and Takemura، نويسنده , , Yuko and Ju-ichi، نويسنده , , Motoharu and Yano، نويسنده , , Masamichi and Ito، نويسنده , , Chihiro and Furukawa، نويسنده , , Hiroshi and Mukainaka، نويسنده , , Teruo and Kuchide، نويسنده , , Masashi and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
7
To page
9
Abstract
Nobiletin and 3,5,6,7,8,3′,4′-heptamethoxyflavone (HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter. HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.
Keywords
Chemopreventive agent , Nobiletin , 3 , 6 , 7 , 3? , 8 , 4?-Heptamethoxyflavone , Nor1 , 5
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802102
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