Title of article
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis
Author/Authors
Tanaka، نويسنده , , Reiko and Minami، نويسنده , , Toshifumi and Tsujimoto، نويسنده , , Kazuhiro and Matsunaga، نويسنده , , Shunyo and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Terada، نويسنده , , Yukimasa and Yoshitake، نويسنده , , Akira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
119
To page
126
Abstract
Seven serratane-type triterpenoids isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayer) Rehder (Pinaceae) were studied their possible inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All compounds showed strong inhibitory effects on the EBV-EA activation, being stronger than that of oleanolic acid, which exerts on cancer preventive activity in animal carcinogenesis models. Among these compounds, 13α, 14α-epoxy-3β-methoxyserratan-21β-ol and 3β-methoxy-21α-hydroxyserrat-14-en-29-al were investigated for the inhibitory effects in a two-stage mouse skin carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter. 13α,14α-Epoxy-3β-methoxyserratan-21β-ol was found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test.
Keywords
Anti-tumor promoter , 13? , Pinaceae , 14?-epoxy-3?-methoxyserratan-21?-ol , Epstein–Barr virus , Two stage carcinogenesis , Serratane , Picea jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayer) , Picea jezoensis (Sieb. et Zucc.) Carr. jezoensis , Triterpenoid
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1803112
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