Title of article
Increased expression of sialyl Lewisx antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer
Author/Authors
Nakagoe، نويسنده , , Tohru and Fukushima، نويسنده , , Kiyoyasu and Sawai، نويسنده , , Terumitsu and Tsuji، نويسنده , , Takashi and Jibiki، نويسنده , , Masa-aki and Nanashima، نويسنده , , Atsushi and Tanaka، نويسنده , , Kenji and Yamaguchi، نويسنده , , Hiroyuki and Yasutake، نويسنده , , Toru and Ayabe، نويسنده , , Hiroyoshi and Arisawa، نويسنده , , Kokichi and Ishikawa، نويسنده , , Hiroshi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
9
From page
213
To page
221
Abstract
Immunohistochemically detected expression of sialyl Lewisx (Lex) antigen was analyzed in 101 stage 0–II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Lex antigen within their tumors had shorter disease-specific intervals than those with negative- or low-expressing tumors (P<0.0001). This difference was noted particularly in stage I-B or II disease. Multivariate Coxʹs regression analysis revealed sialyl Lex antigen expression to be an independent predictor of disease-specific survival (Hazard ratio=9.10). In conclusion, the increased expression of sialyl Lex antigen may serve as a prognostic factor after curative surgery for stages 0–II gastric cancer.
Keywords
Prognostic factor , sialyl Lex , Gastric cancer
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803398
Link To Document