Title of article
Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds
Author/Authors
Nakamura، نويسنده , , Eliane S and Kurosaki، نويسنده , , Fumiya and Arisawa، نويسنده , , Munehisa and Mukainaka، نويسنده , , Teruo and Okuda، نويسنده , , Masato and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Pastore Jr.، نويسنده , , Floriano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
6
From page
119
To page
124
Abstract
Summary
ti-tumor promoting effects of fruits of Caesalpinia ferrea Mart. (Leguminosae) were tested by the in vitro Epstein–Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity.
Keywords
EBV-EA activation assay , Anti-tumor promotion , acetophenone , Caesalpinia ferrea , Gallic acid , Methyl gallate
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803573
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