Title of article
Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib
Author/Authors
Patti، نويسنده , , Ratnakar and Gumired، نويسنده , , Kiranmai and Reddanna، نويسنده , , Pallu and Sutton، نويسنده , , Leslie N. and Phillips، نويسنده , , Peter C. and Reddy، نويسنده , , C.Damodar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
9
From page
13
To page
21
Abstract
In this study the role of cyclooxygenase-2 (COX-2) in primitive neuroectodermal tumor (PNET) the most malignant brain tumors of childhood was investigated. COX-2 expression in human brain tumor biopsy samples (seven/seven) was about 6–8-fold higher than normal brain tissue and several PNET cell lines also express COX-2. The effect of selective COX-2 inhibitors, celecoxib and rofecoxib on the growth of two PNET cell lines (DAOY and PFSK) was determined. Celecoxib was more potent than rofecoxib in suppressing cell growth. Growth inhibition by celecoxib and rofecoxib was independent of Bcl-2 expression. Celecoxib suppressed the expression of Akt and activated the caspase-3 in DAOY and PFSK, whereas rofecoxib did not have such an effect.
Keywords
Cyclooxygenases , Celecoxib , ROFECOXIB , Primitive neuroectodermal tumors , caspase-3
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803835
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