Title of article
Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors
Author/Authors
Nicklin، نويسنده , , Stuart A. and Dishart، نويسنده , , Kate L. and Buening، نويسنده , , Hildegard and Reynolds، نويسنده , , Paul N. and Hallek، نويسنده , , Michael and Nemerow، نويسنده , , Glen R. and Von Seggern، نويسنده , , Dan J. and Baker، نويسنده , , Andrew H.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
9
From page
165
To page
173
Abstract
Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction in a panel of cancer cells. Six of twelve lines (C8161, PC-3, G-CCM, MKN-45, LnCAP and A549) were transduced, independently of native viral tropism. Furthermore the candidate cancer gene therapy promoter FLT-1 was active in three of these six cell lines. This offers the potential for dual targeting of selected cancer cells.
Keywords
Gene Therapy , adenovirus , Adeno-associated Virus , TARGETING , Promoter
Journal title
Cancer Letters
Serial Year
2003
Journal title
Cancer Letters
Record number
1805725
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