Title of article
Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China
Author/Authors
An، نويسنده , , Yan and Gao، نويسنده , , Zenglin and Wang، نويسنده , , Zhongwen and Yang، نويسنده , , Shaohe and Liang، نويسنده , , Jianfen and Feng، نويسنده , , Yan and Kato، نويسنده , , Koichi and Nakano، نويسنده , , Masayuki and Okada، نويسنده , , Shoji and Yamanaka، نويسنده , , Kenzo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
11
To page
18
Abstract
The appearance of 8-oxo-2′-deoxyguanosine (8-oxodG) was examined immunohistochemically using an 8-oxodG-monoclonal antibody in 28 cases of arsenic-related human skin tumors and in 20 cases of arsenic-unrelated human skin cancer to determine if the induction of oxidative stress participates in skin tumorigenesis caused by arsenics. The rate of 8-oxodG-positive was significantly higher in arsenic-related human skin cancer (28 of 28, 100%) than in arsenic-unrelated human skin cancer (3 of 20, 15%, P<0.01 by χ2 test). Moreover, in all the arsenic-related skin samples, 8-oxodG was detected not only in tumor tissues but also in keratosis and normal tissues. These results suggest that the induction of oxidative stress may play an important role in arsenic carcinogenesis.
Keywords
Free radicals , 8-Oxo-2?-deoxyguanosine (8-oxodG) , Arsenic-related human skin cancers , oxidative stress
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1806949
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