Title of article
Lymphotoxin-α polymorphism and the risk of cervical cancer in Japanese subjects
Author/Authors
Niwa، نويسنده , , Yoshimitsu and Hirose، نويسنده , , Kaoru and Matsuo، نويسنده , , Keitaro and Tajima، نويسنده , , Kazuo and Ikoma، نويسنده , , Yoko and Nakanishi، نويسنده , , Toru and Nawa، نويسنده , , Akihiro and Kuzuya، نويسنده , , Kazuo and Tamakoshi، نويسنده , , Akiko and Hamajima، نويسنده , , Nobuyuki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
63
To page
68
Abstract
To examine the possible association between cervical cancer and Lymphotoxin-α (LTα) polymorphisms, C804A and A252G, an incident case–control study was conducted in Japanese. The cases were 131 cervical cancer patients. Controls were 320 healthy women. Risk estimation was conducted by an unconditional logistic model. Complete linkage disequilibrium was seen between LTα C804A and LTα A252G. We found that, compared with the 804CC genotype, 804CA and 804AA were associated with a decreased risk of cervical cancer (OR=0.64, 95% CI=0.40–1.02; and OR=0.45, 95% CI=0.21–0.95, respectively), especially of SCC (OR=0.54, 95% CI=0.32–0.91; and OR=0.39, 95% CI=0.16–0.92, respectively).
Keywords
LT? C804A polymorphism , LT? A252G polymorphism , cervical cancer , Polymerase chain reaction with confronting two-pair primers
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1807355
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