Title of article
Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells
Author/Authors
Lord، نويسنده , , Jean L. and de Peyster، نويسنده , , Ann and Quintana، نويسنده , , P.J.E. and Metzger، نويسنده , , Robert P.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
119
To page
124
Abstract
Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 μM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109±13 μM (mean±SEM of y estimate) and 103±9 μM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.
Keywords
cytotoxicity , MF-7 cells , Xanthopterin , Isoxanthopterin , Pterins , Pteridines
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1807810
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