Title of article
Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
Author/Authors
Nithipatikom، نويسنده , , Kasem and Isbell، نويسنده , , Marilyn A. and See، نويسنده , , William A. and Campbell، نويسنده , , William B.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
7
From page
219
To page
225
Abstract
The role of eicosanoids (metabolites of arachidonic acid) in prostate diseases is receiving increased attention. We investigated the relationship between the concentrations of urinary free acids of 12- and 20-hydroxyeicosatetraenoic acids (12- and 20-HETE) and the benign prostatic hypertrophy (BPH) and prostate cancer (Pca). Urinary concentrations of 12-HETE and 20-HETE of BPH and Pca patients were significantly higher than normal subjects. After removal of the prostate gland, the urinary concentrations of these eicosanoids decreased to concentrations similar to the normal subjects. These results suggest that urinary free acids of 12-HETE and 20-HETE indicate an abnormality of the prostate gland.
Keywords
Benign prostatic hypertrophy (BPH) , prostate cancer , 12-HETE , 20-HETE
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809016
Link To Document