Title of article
The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: Interaction between areca chewing and smoking
Author/Authors
Lin، نويسنده , , Ying-Chu and Wu، نويسنده , , Deng-Chyang and Lee، نويسنده , , Jang-Ming and Hsu، نويسنده , , Hon-Ki and Kao، نويسنده , , Ein-Long and Yang، نويسنده , , Chien-Hui and Wu، نويسنده , , Ming-Tsang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
281
To page
288
Abstract
One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His113 polymorphisms, the risk of contracting ESCC for participants with His113His who chewed areca and smoked was >50% less than for those with Thy113Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC.
Keywords
Esophageal cancer , genotype , Smoking , Areca chewing , Microsomal epoxide hydrolase
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809397
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