Title of article
Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer
Author/Authors
Wang، نويسنده , , Jun and Wu، نويسنده , , Kaichun and Bai، نويسنده , , Feihu and Zhai، نويسنده , , Huihong and Xie، نويسنده , , Huahong and Du، نويسنده , , Yulei and Liang، نويسنده , , Jie and Han، نويسنده , , Shuang and Chen، نويسنده , , Yu and Lin، نويسنده , , Tao and Fan، نويسنده , , Daiming، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
20
To page
27
Abstract
We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl2 treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1α pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression.
Keywords
angiopoietin , cyclooxygenase , Gastric cancer , Hypoxia , Angiogenesis
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809781
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