Title of article
CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
Author/Authors
He، نويسنده , , Lijie and Wang، نويسنده , , Hanmin and Jin، نويسنده , , Haifeng and Guo، نويسنده , , Changcun and Xie، نويسنده , , Huahong and Yan، نويسنده , , Kun and Li، نويسنده , , Xiaohuai and Shen، نويسنده , , Qing An Qiao، نويسنده , , Taidong and Chen، نويسنده , , Guanglei and Chai، نويسنده , , Na Na Zhao، نويسنده , , Lina and Dong، نويسنده , , Qingchuan and Zheng، نويسنده , , Yan and Liu، نويسنده , , Jie and Fan، نويسنده , , Daiming، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
88
To page
94
Abstract
Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues (P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
Keywords
CIAPIN1 , G1/S , Clear cell renal cell carcinoma , Proliferation , VEGF
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813515
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