FORMULATION AND IN-VITRO EVALUATION OF AMOXICILLIN CLAVULANATE POTASSIUM TABLET

The antibiotics are available in many formulations in the market like solid dosage forms, liquid dosage forms, parental preparations etc. Amoxicillin clavulanate potassium acting as an antibiotic used in the treatment of patients with acquired pneumonia or acute bacterial sinusitis due to confirmed or suspected beta lactamase pathogens. It is an analog derived from the basic penicillin nucleus, 6-aminopencillanic acid. Totally nine formulations were made with different concentrations of coating polymers such as ethyl cellulose, hypromellose, opadry white and other ingredients were used in the same concentrations. Amoxicillin clavunate potassium tablets (cores) were prepared by direct compression method and coating of polymer to the tablets was done using pan coating. Tablets were evaluated for thickness, weight variation, hardness, friability, in – vitro dispersion time, disintegration time and dissolution study. Tablets shows uniform weight, hardness and friability data indicates good mechanical resistance of the tablets. Prepared tablets were evaluated for the disintegration test; all the tablets were disintegrated between 12 to 14th minute. The formulation F6 shows best disintegration time. The prepared formulations (F1 to F9) were subjected for dissolution studies. Among all the formulations F6 shows better dissolution profile of 104.7% and 104.2 % drug release at 30th minute. This value is better when compared even with marketed formulation.