Title of article
Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma
Author/Authors
Furutani، نويسنده , , Masaharu and Arii، نويسنده , , Shigeki and Tanaka، نويسنده , , Hisashi and Mise، نويسنده , , Masahiro and Niwano، نويسنده , , Mototaka and Harada، نويسنده , , Tomika and Higashitsuji، نويسنده , , Hiroaki and Imamura، نويسنده , , Masayuki and Fujita، نويسنده , , Jun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
7
From page
191
To page
197
Abstract
CIP1/WAF1, a critical downstream effector of tumor suppressor p53, encodes a cyclin-dependent kinase inhibitor. By Northern blot analysis, the CIP1/WAF1 mRNA level in the tumor was significantly lower than that in the corresponding normal liver from 19 Japanese patients with hepatocellular carcinoma (P < 0.05). In the tumor from only one out of 19 patients (5%), somatic mutations of the CIP1/WAF1 as well as that of p53 gene were identified by RT-PCR/SSCP analysis. These results suggest that the decreased CIP1/WAF1 expression is involved in the carcinogenesis or the progression of hepatocellular carcinoma.
Keywords
p53 , Cyclin-dependent kinase , CIP1 , WAF1 , p21 , hepatocellular carcinoma
Journal title
Cancer Letters
Serial Year
1997
Journal title
Cancer Letters
Record number
1815309
Link To Document