Title of article
Monosomy 1p is correlated with enhanced in vivo glucose metabolism in meningiomas
Author/Authors
Henn، نويسنده , , Wolfram and Cremerius، نويسنده , , Uwe and Heide، نويسنده , , Günther and Lippitz، نويسنده , , Bodo and Schrِder، نويسنده , , J.Michael and Gilsbach، نويسنده , , Joachim M. and Bullb، نويسنده , , Udalrich and Zang، نويسنده , , Klaus D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
5
From page
144
To page
148
Abstract
The 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake of 25 human meningiomas was preoperatively evaluated in vivo by positron-emission tomography (PET). After surgery, meningioma biopsies were analyzed cytogenetically. Five meningiomas showed partial monosomy for chromosome 1p additional to other typical chromosome aberrations. This aberrant karyotype was correlated with increased FDG uptake. Three of five meningiomas with monosomy 1p were classified as grade II according to WHO, while only one of 20 tumors without monosomy 1p was classified as grade II. Thus, monosomy 1p and elevated FDG uptake in PET are to be regarded as cytogenetic and metabolic parameters for the aggressiveness of meningiomas.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
1995
Journal title
Cancer Genetics and Cytogenetics
Record number
1817350
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