Title of article
MicroRNA in pancreatic cancer: Pathological, diagnostic and therapeutic implications
Author/Authors
Rachagani، نويسنده , , Satyanarayana and Kumar، نويسنده , , Sushil and Batra، نويسنده , , Surinder K.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
9
From page
8
To page
16
Abstract
MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17–25 nucleotides (nt) in length, predicted to control the activity of about 30% of all protein-coding genes in mammals. Altered expressions of miRNAs are reported in various cancers and may associate with cancer pathogenesis, apoptosis, and cell growth, thereby functioning as either tumor suppressors or oncogenes. Recent reports showed that deregulation of miRNA contribute to tumor development and progression and hence, have diagnostic and prognostic value in several human malignancies. This review discusses the current status of miRNA in pancreatic cancer development, progression, diagnosis, and therapy.
Keywords
MicroRNA , pancreatic cancer , Diagnosis and therapy
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818564
Link To Document