Title of article
PTHrP stimulates prostate cancer cell growth and upregulates aldo–keto reductase 1C3
Author/Authors
Downs، نويسنده , , Tracy M. and Burton، نويسنده , , Douglas W. and Araiza، نويسنده , , Flavio L. and Hastings، نويسنده , , Randolph H. and Deftos، نويسنده , , Leonard J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
8
From page
52
To page
59
Abstract
The aim of the study was to demonstrate the role of parathyroid hormone related protein (PTHrP) in stimulating aldo–keto reductase (AKR) 1C3 expression in prostate cancer (CaP) cells. CaP cell proliferation and resistance to apoptosis was increased by PTHrP transfection. Conversely, reducing AKR1C3 expression by siRNA decreased cell proliferation. Since these effects could be mediated through AKR1C3-catalyzed reductions of the PPARγ ligand, 15-DeoxyΔ12,14-PGJ2, we treated the cells with prostaglandins (PG). (PG) D2 inhibited cell proliferation, but its metabolite, 9α,11β-PGF2, did not effect CaP cell growth. The AKR1C family members serve as potential therapeutic targets for CaP therapy.
Keywords
Androgens , prostaglandins , apoptosis , tumor markers
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1819871
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