Title of article
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: Efficacy and underlying mechanisms
Author/Authors
Mueller، نويسنده , , Sabine and Yang، نويسنده , , Xiaodong and Sottero، نويسنده , , Theo L. and Gragg، نويسنده , , Ashley and Prasad، نويسنده , , Gautam and Polley، نويسنده , , Mei-Yin and Weiss، نويسنده , , William A. and Matthay، نويسنده , , Katherine K. and Davidoff، نويسنده , , Andrew M. and DuBois، نويسنده , , Steven G. and Haas-Kogan، نويسنده , , Daphne A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
7
From page
223
To page
229
Abstract
Histone deacetylase (HDAC) inhibitors can radiosensitize cancer cells. Radiation is critical in high-risk neuroblastoma treatment, and combinations of HDAC inhibitor vorinostat and radiation are proposed for neuroblastoma trials. Therefore, we investigated radiosensitizing effects of vorinostat in neuroblastoma. Treatment of neuroblastoma cell lines decreased cell viability and resulted in additive effects with radiation. In a murine metastatic neuroblastoma in vivo model vorinostat and radiation combinations decreased tumor volumes compared to single modality. DNA repair enzyme Ku-86 was reduced in several neuroblastoma cells treated with vorinostat. Thus, vorinostat potentiates anti-neoplastic effects of radiation in neuroblastoma possibly due to down-regulation of DNA repair enzyme Ku-86.
Keywords
radiation , Metastatic neuroblastoma , DNA repair , Vorinostat
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1819961
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