Title of article
piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells
Author/Authors
Cheng، نويسنده , , Jia and Deng، نويسنده , , Hongxia and Xiao، نويسنده , , Bingxiu and Zhou، نويسنده , , Hui and Zhou، نويسنده , , Fei and Shen، نويسنده , , Zhisen and Guo، نويسنده , , Junming، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
6
From page
12
To page
17
Abstract
Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer.
Keywords
Gastric cancer , PiRNA , non-coding RNA , Carcinogenesis
Journal title
Cancer Letters
Serial Year
2012
Journal title
Cancer Letters
Record number
1820855
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