Title of article
Novel Breakpoints of the EWS Gene and the WT1 Gene in a Desmoplastic Small Round Cell Tumor
Author/Authors
Shimizu، نويسنده , , Yukitoshi and Mitsui، نويسنده , , Tetsuo and Kawakami، نويسنده , , Takako and Ikegami، نويسنده , , Tohru and Kanazawa، نويسنده , , Chikako and Katsuura، نويسنده , , Michihiko and Obata، نويسنده , , Kazuya and Yamagiwa، نويسنده , , Iwao and Hayasaka، نويسنده , , Kiyoshi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
3
From page
156
To page
158
Abstract
We report here a 15-year-old boy with an intraabdominal desmoplastic small round cell tumor (DSRCT). Cytogenetic analysis of the tumor cells showed the chromosomal translocation (11;22). Reverse-transcriptase polymerase chain reaction and sequencing analysis revealed a chimeric transcriptional message of the EWS gene exon 10 fused to the WT1 gene exon 8. The typical chimeric transcript seen in DSRCT is an in-frame fusion of EWS exon 7 to WT1 exon 8. The tumor in this case had a novel and longer chimeric transcript, which should be a potent transcription factor. Genetic analysis is a very powerful and specific aid in the differential diagnosis of small round cell tumors.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
1998
Journal title
Cancer Genetics and Cytogenetics
Record number
1821516
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