Title of article
Analysis of 3p Allelic Losses in Renal Cell Carcinomas: Comparison with Cytogenetic Results
Author/Authors
Bernués، نويسنده , , Marta and Casadevall، نويسنده , , Carme and Mir?، نويسنده , , Rosa and Caball??n، نويسنده , , Mar??a Rosa and Gelabert، نويسنده , , Antoni and Ejarque، نويسنده , , Mar??a José and Chéchile، نويسنده , , Gilberto and Egozcue، نويسنده , , José، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
121
To page
124
Abstract
We performed a study of loss of heterozygosity (LOH) at 3p by restriction fragment length polymorphism analysis in a series of 22 renal tumors. In 11 cases, molecular results could be compared with those of cytogenetic studies. The highest frequency of allelic losses at 3p was seen in clear cell nonpapillary renal tumors, whereas none of the papillary renal cell carcinomas showed LOH at 3p. Allelic losses on 3p were found to be independent of tumor grade or stage or both. One case analyzed showed a discrepancy between cytogenetic and LOH studies. This tumor displayed rearrangements of chromosome 3 and no LOH at the c-RAF-1 (close to the Von Hippel Lindau gene) locus.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
1998
Journal title
Cancer Genetics and Cytogenetics
Record number
1821623
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