Title of article
HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis
Author/Authors
Lee، نويسنده , , Hyunseung and Jung، نويسنده , , Kyung Hee and Jeong، نويسنده , , Yujeong and Hong، نويسنده , , Sungwoo and Hong، نويسنده , , Soon-Sun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
8
From page
152
To page
159
Abstract
We synthesized a novel imidazopyridine analogue, a PI3Kα inhibitor HS-173 and investigated anti-cancer capacity in human cancer cells. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G2/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.
Keywords
PI3K inhibitor , anti-cancer drug , apoptosis , Angiogenesis
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1822109
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