Title of article
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway
Author/Authors
Meng، نويسنده , , Xiaojing and Cai، نويسنده , , Chunqing and Wu، نويسنده , , Jiguo and Cai، نويسنده , , Shaoxi and Ye، نويسنده , , Changsheng and Chen، نويسنده , , Haiyang and Yang، نويسنده , , Zhengduo and Zeng، نويسنده , , Hongqiang and Shen، نويسنده , , Qiang and Zou، نويسنده , , Fei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
7
From page
96
To page
102
Abstract
Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway.
Keywords
breast cancer , TRPM7 , Invasion , Src , MAPK
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1822716
Link To Document