Title of article
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII
Author/Authors
Chu، نويسنده , , Ting-Hui and Yang، نويسنده , , Cheng-Chieh and Liu، نويسنده , , Chung-Ji and Lui، نويسنده , , Mann-Tin and Lin، نويسنده , , Shu-Chun and Chang، نويسنده , , Kuo-Wei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
10
From page
115
To page
124
Abstract
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.
Keywords
c-Myc , carcinoma , head and neck , TGF?RII , miR-211 , Transgenic mouse
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1823378
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