Title of article
Proteomics-based identification of the tumor suppressor role of aminoacylase 1 in hepatocellular carcinoma
Author/Authors
Wei، نويسنده , , Xuyong and Li، نويسنده , , Jie and Xie، نويسنده , , Haiyang and Ling، نويسنده , , Qi and Wang، نويسنده , , Jianguo and Lu، نويسنده , , Di and Zhou، نويسنده , , Lin and Xu، نويسنده , , Xiao and Zheng، نويسنده , , Shusen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
9
From page
117
To page
125
Abstract
The present work aimed to investigate the expression and role of aminoacylase 1 (ACY1) in hepatocellular carcinoma (HCC) based on a proteomic study. The study results revealed that the expression of ACY1 was much lower in HCC tissues. ACY1 expression significantly correlated with the serum alpha fetoprotein level and tumor invasiveness. The knockdown of ACY1 in SMMC7721 cells promoted cell viability and invasiveness. In contrast, the restoration of ACY1 in BEL7402 cells inhibited cell viability and invasiveness. Further studies indicated that the knockdown of ACY1 increased the protein expression of transforming growth factor beta 1 and extracellular signal-regulated kinase 1 expression. The study’s results indicated that ACY1 acts as a tumor suppressor in HCC.
Keywords
proteomic , Aminoacylase 1 , hepatocellular carcinoma , Tumor suppressor
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1824789
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