Title of article
Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1
Author/Authors
de Oliveira، نويسنده , , Fلbio Morato and Tone، نويسنده , , Luiz Gonzaga and Simُes، نويسنده , , Belinda Pinto and Falcمo، نويسنده , , Roberto Passetto and Brassesco، نويسنده , , Marيa Sol and Sakamoto-Hojo، نويسنده , , Elza Tiemi and Silva dos Santos، نويسنده , , Guilherme Augusto and Marinato، نويسنده , , André Fiorin and Jلcomo، نويسنده , , Rafael Henriques Candiago، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
154
To page
157
Abstract
We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase–polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2007
Journal title
Cancer Genetics and Cytogenetics
Record number
1828190
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