Title of article
Rearrangements involving 12q in myeloproliferative disorders: possible role of HMGA2 and SOCS2 genes
Author/Authors
Etienne، نويسنده , , Anne and Carbuccia، نويسنده , , Nadine and Adélaïde، نويسنده , , José and Bekhouche، نويسنده , , Ismahane and Rémy، نويسنده , , Virginie and Sohn، نويسنده , , Claudine and Sainty، نويسنده , , Danielle and Gastaut، نويسنده , , Jean-Albert and Olschwang، نويسنده , , Sylviane and Birnbaum، نويسنده , , Daniel and Mozziconacci، نويسنده , , Marie-Joëlle and Chaffanet، نويسنده , , M، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
9
From page
80
To page
88
Abstract
We report two cases of translocation associated with deletion on derivative chromosomes in atypical myeloproliferative disorder (MPD). In a MPD with t(3;12)(q29;q14), the rearrangement targeted the HMGA2 locus at 12q14 and deleted a region of about 1.5 megabases (Mb) at 3q29. In an MPD with t(9;12)(q13∼q21;q22) and JAK2 V617F mutation, array comparative genomic hybridization delineated a deletion of about 3 Mb at 9q13∼q21 and a deletion of about 2 Mb at 12q22 containing SOCS2. These results show that close examination of translocations in hematopoietic diseases may reveal associated microdeletions. The role of these deletions is discussed.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2007
Journal title
Cancer Genetics and Cytogenetics
Record number
1828420
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