Title of article
A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement
Author/Authors
La Starza، نويسنده , , Roberta and Brandimarte، نويسنده , , Lucia and Pierini، نويسنده , , Valentina and Nofrini، نويسنده , , Valeria and Gorello، نويسنده , , Paolo and Crescenzi، نويسنده , , Barbara and Berchicci، نويسنده , , Laura and Matteucci، نويسنده , , Caterina and Romoli، نويسنده , , Silvia and Beacci، نويسنده , , Donatella and Rosati، نويسنده , , Roberto and Martelli، نويسنده , , Massimo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
3
From page
109
To page
111
Abstract
We report a case of adult acute myeloid leukemia with a new t(11;12)(p15;q13) underlying a NUP98 rearrangement without HOXC cluster gene involvement. We designed a specific double-color double-fusion FISH assay to discriminate between this t(11;12)(p15;q13) and those producing NUP98-HOXC11 or NUP98-HOXC13. Our fluorescence in situ hybridization (FISH) showed that putative candidate partners mapping 600 kilobases centromeric to HOXC were RARG (retinoic acid receptor γ), MFSD5 (major facilitator superfamily domain containing 5), and ESPL1 (extra spindle pole bodies homolog 1). It is noteworthy that so far only ESPL1 has been implicated in human cancers. This FISH assay is useful for diagnostic screening of NUP98-positive leukemias.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2009
Journal title
Cancer Genetics and Cytogenetics
Record number
1829880
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