High-resolution MR spectroscopy via intermolecular double-quantum coherences in inhomogeneous B0 and B1 fields

Inhomogeneity in static field B0 and/or RF field B1 is inevitable under some circumstances. In this work, a method based on intermolecular double-quantum coherences is employed for high-resolution 1D MR spectroscopy via 2D acquisition under such a condition. High-resolution information on chemical shifts, multiplet patterns, J coupling constants and relative peak areas can be retained in the resulting 1D projected spectra, as shown with results from a narrow-bore NMR spectrometer and a whole-body clinical scanner.