Title of article
Access to lincomycin N-oxide isomers controlled by reaction conditions
Author/Authors
Posp???il، نويسنده , , Stanislav and Sedmera، نويسنده , , Petr and Halada، نويسنده , , Petr and Havlicek، نويسنده , , Libor and Sp???ek، نويسنده , , Jaroslav، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
2943
To page
2945
Abstract
Oxidation of lincomycin with H2O2 in alkaline media leads to N-oxides, besides the conversion of thiomethyl group into sulfoxides and sulfones. NH4OH favors formation of the S-isomer; both R- and S-isomers of the N-oxide are formed in the presence of NaOH. Addition of acetonitrile markedly accelerates the reaction.
Keywords
Hydrogen peroxide , N-Oxide isomers , alkaline , Lincomycin oxidation , Acetonitrile
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841213
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