Title of article
A rapid catalytic asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines
Author/Authors
Belyk، نويسنده , , Kevin M. and Beguin، نويسنده , , Charlotte D. and Palucki، نويسنده , , Michael and Grinberg، نويسنده , , Nelu and DaSilva، نويسنده , , Jimmy and Askin، نويسنده , , David and Yasuda، نويسنده , , Nobuyoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3265
To page
3268
Abstract
The asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines was accomplished in two steps from readily available starting materials. A 1,3-dipolar cycloaddition of an azomethine ylide to a propiolate ester followed by a Rh-catalyzed asymmetric 1,4-arylation of the resulting pyrroline with an arylboronic acid provided the desired 1,3,4-trisubstituted pyrrolidine products in good to excellent enantioselectivities.
Keywords
4-addition , Asymmetric 1 , 1 , pyrrolidine , Arylboronic acid , Rhodium-catalyzed , 3-dipolar cycloaddition
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841340
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