Title of article
Total synthesis of nothapodytine B and (±)-mappicine
Author/Authors
Chavan، نويسنده , , Subhash P. and Sivappa، نويسنده , , Rasapalli Sivappa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
3941
To page
3943
Abstract
A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B (2, mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assembly of a pyridone D ring precursor with the necessary functionalities. Nothapodytine B is converted into mappicine 3 by NaBH4 reduction.
Keywords
total synthesis , Mappicine , Nothapodytine B , Johnson orthoester rearrangement , Pyridone
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841611
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