• Title of article

    Copper(I)-catalyzed asymmetric alkene aziridination mediated by PhI(OAc)2: a facile one-pot procedure

  • Author/Authors

    Kwong، نويسنده , , Hoi-Lun and Liu، نويسنده , , Di-Sien Chan، نويسنده , , Ka Yee C Lee، نويسنده , , Chi-Sing and Huang، نويسنده , , Ka-Hung and Che، نويسنده , , Chi-Ming، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2004
  • Pages
    4
  • From page
    3965
  • To page
    3968
  • Abstract
    A facile one-pot procedure for copper-catalyzed PhI(OAc)2-mediated asymmetric alkene aziridination had been developed. Commercially available PhI(OAc)2 and sulfonamides were used to generate the nitrene precursors (PhINR) in situ for olefin aziridination. This one-pot procedure had been optimized using 4-nitrobenzenesulfonamide as the nitrene source. With 5 mol % of the chiral copper catalyst, these conditions afforded 94% yield of the isolated product with 75% ee. We had also developed a simple and rapid method to monitor the rate of this one-pot aziridination.
  • Keywords
    One-pot asymmetric aziridination , copper catalyst , iodobenzene diacetate , sulfonamides , styrene
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2004
  • Journal title
    Tetrahedron Letters
  • Record number

    1841620

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1841620