Title of article
Application of polydentate chiral amines within magnesium-mediated asymmetric deprotonation reactions
Author/Authors
Bassindale، نويسنده , , Martin J. and Crawford، نويسنده , , James J. and Henderson، نويسنده , , Kenneth W. and Kerr، نويسنده , , William J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
4175
To page
4179
Abstract
A set of polydentate secondary amines, each containing two stereogenic centres, were prepared. These were subsequently utilised in magnesium-mediated asymmetric deprotonation reactions and excellent enantiomeric ratios were obtained (up to 94:6 er). Furthermore, these bases tend to be highly efficient in the absence of strong Lewis base additives, which demonstrates an additional practical advantage over existing protocols.
Keywords
asymmetric synthesis , Magnesium amides , enantioselective deprotonation , chiral amines
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841716
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