Title of article
Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters
Author/Authors
Jan Rijn Zeevaart and، نويسنده , , Jacob G. and Parkinson، نويسنده , , Christopher J. and de Koning، نويسنده , , Charles B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
4261
To page
4264
Abstract
The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K3PO4 is described. The arylated acetoacetate ester is de-acylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters.
Keywords
Palladium catalysis , Enolate arylation , Arylacetic acid esters
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841763
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