Elaboration of a novel effective approach to enantiopure functionalised 2,2′-dialkyl-1,1′-binaphthyls by stereoconservative cross-couplings at positions 2 and 2′

The yield and the stereochemical outcome of methylations of 1,1′-binaphthyl-2,2′-dielectrophiles (ditriflate and diiodide) clearly depend on the reactivity of the organometallics used. It was found that only the Negishi reaction of a diiodide allows direct effective synthesis of non-racemic functionalised C2-symmetric 2,2′-dialkyl-1,1′-binaphthyls.