Use of highly reactive, versatile and air-stable palladium–phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki–Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids

Using highly reactive air-stable palladium–phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst, synthesis of heteroaryl–aryl cross-coupled products via palladium-catalyzed Suzuki–Miyaura coupling of less reactive substituted 3-chloropyridines with arylboronic acids was achieved in high yields.