Title of article
Synthesis of benzyl- and benzhydrylferrocenes via Friedel–Crafts alkylation of ferrocene. Access to ferrocenyl bisphenols with high affinities for estrogen receptors
Author/Authors
Damian Plazuk، نويسنده , , Damian and Vessières، نويسنده , , Anne and Le Bideau، نويسنده , , Franck and Jaouen، نويسنده , , Gérard and Zakrzewski، نويسنده , , Janusz، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
5425
To page
5427
Abstract
Ferrocene reacts with methoxy-substituted benzyl- and benzhydryl alcohols in the presence of trifluoroacetic acid to afford methoxybenzyl- or benzhydrylferrocenes in 47–56% yield. Demethylation of these compound leads to the ferrocenyl phenols and bisphenols. Some of the synthesized compounds display high affinity for estrogen receptors ERα and ERβ.
Keywords
Ferrocene , Estrogen receptor , Friedel–Crafts alkylation , Bisphenol
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842393
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