Title of article
First total synthesis of verbalactone, a macrocyclic dilactone isolated from Verbascum undulatum
Author/Authors
Gogoi، نويسنده , , Siddhartha and Barua، نويسنده , , Nabin C. and Kalita، نويسنده , , Biswajit، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
5577
To page
5579
Abstract
Verbalactone, a new macrocyclic dilactone was synthesized efficiently in a steroselective manner involving a Barbier–Grignard reaction, a Sharpless asymmetric dihydroxylation, monotosylation, epoxidation, ring opening of the epoxide, hydrolysis and lactonization. A δ-lactone, (+)-(3R,5R)-3-hydroxy-5-decanolide was also formed along with the dimeric lactone.
Keywords
Macrocyclic dilactone , Barbier–Grignard reaction , sharpless asymmetric dihydroxylation , tosylation , kinetic resolution , HMG-CoA reductase , Lactonization , Verbalactone
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842502
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