Title of article
2-Pivalamido-3H-pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO3)3 in MeOH
Author/Authors
Bavetsias، نويسنده , , V. and Henderson، نويسنده , , E.A. and McDonald، نويسنده , , E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
2
From page
5643
To page
5644
Abstract
A simple methodology for pivalamide (trimethylacetamide, pivaloylamino) hydrolysis has been discovered using Fe(NO3)3 in MeOH at room temperature. The pivalamido group of 2-pivalamido-3H-pyrimidin-4-ones or fused 2-pivalamido-3H-pyrimidin-4-ones such as 2-pivalamido-3H-quinazolin-4-ones and 2-pivalamido-3H-pteridines have been hydrolysed under these conditions to afford the corresponding amine.
Keywords
2-Pivalamido-3H-pyrimidin-4-ones , Fe(NO3)3 , Hydrolysis
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842543
Link To Document