Title of article
Synthesis of 6-vinyl and 5-vinylproline analogues of ascomycin
Author/Authors
Bulusu، نويسنده , , Murty A.R.C. and Waldstنtten، نويسنده , , Peter and Tricotet، نويسنده , , Thomas and Rochais، نويسنده , , Christophe and Steck، نويسنده , , Andrea and Bacher، نويسنده , , Markus، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5833
To page
5836
Abstract
6-Vinyl (12) and (5R)- and (5S)-vinylproline (18, 19) analogues of ascomycin are synthesised starting from the known suitably protected (6S)-methoxy-9-hydroxy derivative (4) of ascomycin. The strategy involves hydrolytic cleavage of the Cε–N bond of the pipecolic acid moiety, extension of the amino acid side chain by two or one carbon units, functional group manipulations, Pd-catalysed reinstallation of the Cε–N or Cδ–N bonds, followed by deprotection and oxidation.
Keywords
macrolactam , Phototransformation , 5-Vinylproline , 6-Vinyl ascomycin
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842762
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