Title of article
Synthesis of optically active β-alkyl aspartate via [3,3] sigmatropic rearrangement of α-acyloxytrialkylsilane
Author/Authors
Sakaguchi، نويسنده , , Kazuhiko and Yamamoto، نويسنده , , Masahiro and Kawamoto، نويسنده , , Tetsuo and Yamada، نويسنده , , Takeshi and Shinada، نويسنده , , Tetsuro and Shimamoto، نويسنده , , Keiko and Ohfune، نويسنده , , Yasufumi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5869
To page
5872
Abstract
The synthesis of four types of optically active β-carbon-substituted analogs of threo-β-hydroxy aspartate (THA) and a β-carbon-substituted analog of threo-β-benzyloxy aspartate (TBOA), which are potent blockers of excitatory amino acid transporters in the mammalian central nervous system, via the chirality-transferring ester–enolate Claisen rearrangement of α-acyloxytrialkylsilane is described.
Keywords
threo-?-Hydroxy aspartate , Glutamate transporter , ?-Acyloxysilane , threo-?-Benzyloxy aspartate , Ester–enolate Claisen rearrangement , ?-hydroxysilane
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842781
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