Title of article
Total synthesis of (+)-cylindricine C
Author/Authors
Arai، نويسنده , , Toshiharu and Abe، نويسنده , , Hideki and Aoyagi، نويسنده , , Sakae and Kibayashi، نويسنده , , Chihiro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5921
To page
5924
Abstract
A stereoselective total synthesis of (+)-cylindricine C has been achieved starting with (S)-N-Boc-2-pyrrolidinone. The key elements of this synthesis involve the sequence of reactions including BF3-mediated addition of the allyl Grignard reagent to the cyclic imine, spirocyclization via enamine formation, and intramolecular Michael addition to form the tricyclic core.
Keywords
Cylindricine , Cyclic imine , intramolecular Michael addition , Azaspirocyclization , Grignard reaction
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842807
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