Title of article
Enantio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines through a multicomponent Ugi reaction and their transformation into bicyclic scaffolds
Author/Authors
Banfi، نويسنده , , Luca and Basso، نويسنده , , Andrea and Guanti، نويسنده , , Giuseppe and Riva، نويسنده , , Renata، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
6637
To page
6640
Abstract
A new enantio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines through a multicomponent approach has been developed, using highly reactive pyrrolines 4 as preformed cyclic imines. The pyrrolidines obtained using protected aspartic acid as acid component in the Ugi condensation have been transformed into two epimeric bicyclic lactones 18, 19, which may find an application as external reverse turn inducers.
Keywords
Multicomponent Ugi reaction , Reverse turn inducer , pyrrolines
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843098
Link To Document