Title of article
Reversal of diastereoselection in the addition of Grignard reagents to chiral 2-pyridyl tert-butyl (Ellman) sulfinimines
Author/Authors
Kuduk، نويسنده , , Scott D. and DiPardo، نويسنده , , Robert M. and Chang، نويسنده , , Ronald K. and Ng، نويسنده , , Christina and Bock، نويسنده , , Mark G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
6641
To page
6643
Abstract
Addition of Grignard reagents to chiral tert-butyl sulfinimines derived from pyridine 2-carboxaldehyde affords protected 2-pyridyl amines in high yields and diastereoselectivities. The sense of chiral induction is opposite to that predicted via a chelation-controlled transition state.
Keywords
chiral amines , tert-Butyl sulfinamide , diastereoselection
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843100
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