Title of article
Formal total synthesis of camptothecin via ring-closing metathesis strategy
Author/Authors
Chavan، نويسنده , , Subhash P. and Pasupathy، نويسنده , , Bimal K. and Venkatraman، نويسنده , , M.S. and Kale، نويسنده , , Ramesh R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
6879
To page
6882
Abstract
A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone 3.
Keywords
Anticancer , camptothecin , ring-closing metathesis (RCM) , Pyridone
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843195
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