Title of article
Synthesis of 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives in quest of a drug with low calcemic activity
Author/Authors
Shimizu، نويسنده , , Hitoshi and Shimizu، نويسنده , , Kazuki and Uchiyama، نويسنده , , Yasushi and Sugita، نويسنده , , Atsuko and Mikami، نويسنده , , Tetsuhiro and Yamauchi، نويسنده , , Tsuyoshi and Kato، نويسنده , , Masahiro and Morikawa، نويسنده , , Kazumi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
7837
To page
7841
Abstract
Two 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives have been synthesized in quest of a drug with lower calcemic activity than Maxacalcitol, 22-oxa-1α,25-dihydroxyvitamin D3, being used as antihyperparathyroidism and antipsoriatic drug. Of two 21-nor products obtained, the product carrying one carbon elongated side chain with diethylcarbinol moiety has been found to exhibit comparable differentiation-inducing activity to Maxacalcitol with much lower exhibition of calcemic activity.
Keywords
Vitamin D3 derivative , 22-Oxavitamin D3 derivatives , Separation of activity , Differentiation-inducing activity , Calcemic activity
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843561
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